相关实验视频

Updated: Jul 17, 2025

A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice
05:28

A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice

Published on: May 15, 2019

22.3K

在单次长时间的压力后,神经基因因正常化扰乱的行为和中央神经化学活动

Hurmat Malik1, Muhammad Usman1, Mehreen Arif1

  • 1Department of Pharmacy, COMSATS University Islamabad, Abbottabad, Pakistan.

Frontiers in pharmacology
|September 4, 2023
PubMed
概括

迪奥斯基宁是一种天然化合物,在治疗创伤后应激障碍 (PTSD) 症状方面表现有前途. 它有效地减少了小鼠模型中的焦虑,抑郁和认知缺陷,这表明了对PTSD的潜在治疗应用.

关键词:
行为测试 行为测试在 diosgenin 的基础上.神经化学分析 进行神经化学分析创伤后应激障碍 创伤后应激障碍一个单一的长期压力.

更多相关视频

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice07:13

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice

Published on: October 24, 2018

17.5K
Restraint to Induce Stress in Mice and Rats03:48

Restraint to Induce Stress in Mice and Rats

Published on: December 6, 2024

1.5K

相关概念视频

Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
60.4K
Introduction to Stress and Lifestyle01:27

Introduction to Stress and Lifestyle

Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
139
Physiological Foundation of Stress01:24

Physiological Foundation of Stress

Stress triggers a coordinated physiological response involving the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. This dual activation ensures that the body is prepared for both immediate and prolonged stress management. The process begins with the perception of a stressor. This initial phase activates the SNS, leading to the rapid release of adrenaline (epinephrine) from the adrenal glands.
Role of the Sympathetic Nervous System
Adrenaline triggers the...
83
The Sympathetic Nervous System01:25

The Sympathetic Nervous System

Overview
95.7K
Stress Response System01:21

Stress Response System

The stress response system, also known as the fight-or-flight response, is the body's automatic physiological reaction to perceived threats. Hans Selye introduced the concept of General Adaptation Syndrome (GAS) to describe the predictable pattern of changes that occur in response to stress. GAS consists of three sequential stages: alarm, resistance, and exhaustion. This model helps explain how chronic stress can contribute to health problems.
Alarm stage
In the alarm stage, the body's...
111
Stress and Mental Health01:30

Stress and Mental Health

Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
180