上腺SGLT1或SGLT2作为预测慢性压力下的动脉样硬化,基于计算机算法
Jianyi Li1,2, Lingbing Meng1,2, Dishan Wu1,2
1Department of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
PeerJ
|September 4, 2023
概括
慢性压力和动脉样硬化增加-葡萄糖共运输体 (SGLT) 1和SGLT2在上腺. 这些载体可以预测大动脉和上腺异常,表明上腺损伤的潜在生物标志物.
科学领域:
- 内分泌学 在内分泌学.
- 心血管病理学心血管病理学
- 分子生物学分子生物学
背景情况:
- 慢性压力通过破坏荷尔蒙平衡和器官功能而加剧动脉样硬化.
- 动脉样硬化涉及影响多个器官系统的复杂生理变化.
研究的目的:
- 在慢性压力下对动脉样硬化的小鼠模型中调查上腺病理.
- 确定在动脉样硬化发育期间上腺体中糖共运输体 (SGLT) 1和SGLT2的表达水平和重要性.
主要方法:
- 在老鼠中,由慢性不可预测的压力,高脂肪饮食和Apoe-/-淘汰引起的动脉样.
- 通过超声波评估大动脉变化和对大动脉和上腺的组织学分析.
- 免疫光和免疫组织化学分析SGLT1和SGLT2表达;ROC,SVM和BP神经网络用于预测价值分析.
主要成果:
- 在慢性压力小鼠的上腺体中观察到SGLT1和SGLT2表达的升高.
- 动脉样硬化小鼠表现出大动脉壁加厚,灯光直径减少,上腺异常,包括胀和糖原增加.
- SGLT1和SGLT2的表达水平准确地预测了大动脉和上腺异常.
结论:
- 在上腺体中增加SGLT1和SGLT2表达与慢性压力下的动脉样硬化有关.
- 在这种情况下,SGLT1和SGLT2作为上腺损伤的敏感和特定预测剂.
- 在慢性压力复杂化的动脉样硬化中,SGLT1和SGLT2显示出作为上腺损伤的生物标志物的潜力.
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