开发和验证用于评估PAS患者手术后干扰的诺姆图:一项追溯队列研究
Wenpeng Li1,2, Dongfang Tang3, Qiwei Wang2
1Department of Neurosurgery, Sun Yat-sen Memorial Hospital, Guang Zhou, China.
PeerJ
|September 4, 2023
概括
这项研究开发了一种名图,用于预测在下垂体腺瘤 (PA) 手术后的术后干扰 (SD). 该工具准确识别有风险的患者,有助于更好地临床管理PAS.
科学领域:
- 神经内分泌学神经内分泌学
- 在瘤学瘤学.
- 神经外科 神经外科
背景情况:
- 下垂体腺瘤 (PAs) 是常见的细胞神经内分泌瘤.
- 手术切除是大多数PAS的主要治疗方法.
- 手术后的干扰 (SD) 是PA手术的已知并发症.
研究的目的:
- 开发和验证一个预测性诺米图,用于手术后的干扰 (SD) 在经过 pituitary adenoma (PA) 切除的患者.
- 确定SD的关键手术前预测因素.
- 为改善临床决策和患者管理提供一个工具.
主要方法:
- 对208名经过手术的PAS患者 (2013-2020年) 的回顾性分析.
- LASSO和后勤回归用于识别SD的独立手术前预测因子.
- 使用AUC,Hosmer-Lemeshow测试和决策曲线分析构建和验证名图.
主要成果:
- 手术后SD的发生率为44.23%.
- 六个手术前的因素 (性别,PA类型,CK,Fe,NEFA,MCV) 被确定为名图.
- 诺米图表显示了高的预测准确性 (AUC 0.851培训,0.771验证) 和临床实用性.
结论:
- 已经开发出一种实用且有效的诺米图,用于在PA手术后预测SD.
- 该工具可以帮助临床医生评估和管理PA患者SD风险.
- 诺米图为下垂体手术后个性化患者护理提供了宝贵的见解.
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