简短的亚动力门电刺激同步应用在手腕曲和伸缩肌肉上,不抑制基本震,独立于刺激频率
Christian Metzner1, Adam Stringham2, Brenna Hislop2
1Neuroscience, Brigham Young University, Provo, UT, USA.
Tremor and other hyperkinetic movements (New York, N.Y.)
|September 4, 2023
概括
在摩托神经元值以下的短暂同步电刺激不能有效地抑制基本震 (ET). 这项研究发现,不同频率的震没有显著减少,这表明在ET治疗中可能需要使用其他刺激方法.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
- 神经学 神经学
背景情况:
- 基本震 (ET) 是一种神经疾病,有可能通过低成本,微创电刺激来治疗.
- 以前对ET手腕肌肉同步电刺激的研究产生了不一致的结果.
- 优化刺激参数,特别是频率至关重要,因为先前的研究使用了有限的范围.
研究的目的:
- 为了研究同步,亚摩托神经元值电刺激对基本震的疗效.
- 确定不同刺激频率 (10-150赫兹) 对ET患者震抑制的影响.
主要方法:
- 20名基本震患者接受了短暂的同步电刺激,通过手腕 flexor 和 extensor 肌肉进行电刺激.
- 测试了15种不同的刺激频率 (10-150 Hz).
- 使用手加速和表面电肌图 (sEMG) 在刺激前,期间和后阶段测量震动的强度和频率.
主要成果:
- 在任何测试的刺激频率上都没有观察到震动强度或频率的显著减少.
- 没有发现刺激阶段和频率之间的显著相互作用震的强度或频率,通过手加速或sEMG测量.
- 统计分析证实了测试的刺激范式在基本震中抑制震的无意义.
结论:
- 短暂的同步子运动神经元值电刺激对于减少基本震患者的震是无效的.
- 这些发现表明,需要异步刺激的相互抑制等机制可能更有效.
- 较长的刺激持续时间可能是必要的,同步刺激影响上脊柱震网络.
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