基因预测的腰周长比和冠状动脉疾病:一项特定性别的门德尔随机化研究
Qiang Ye1, Sarah A Gagliano Taliun2,3
1Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.
HGG advances
|September 4, 2023
概括
腰与部比 (WHR) 与女性冠状动脉疾病 (CAD) 风险有因果关系,但与男性无因果关系. 这一特定于性别的发现强调了针对心血管疾病预防和治疗的量身定制方法的必要性.
科学领域:
- 心血管研究研究心血管研究
- 遗传学 是一个遗传学.
- 流行病学 流行病学
背景情况:
- 冠状动脉疾病 (CAD) 构成了全球重大健康负担.
- 现有的CAD风险评估经常忽视性别特异性差异.
- 腰部至部周长率 (WHR) 是比BMI更准确地衡量身体脂肪,并显示基于性别的变化.
研究的目的:
- 以性别特定的方式调查WHR和CAD风险之间的因果关系.
- 为了确定WHR是否是女性和/或男性CAD的因果因素.
- 为了利用遗传数据进行强大的因果推断来理解CAD病因学.
主要方法:
- 以性别为特征的门德尔随机化 (MR) 分析使用英国生物库数据进行.
- 两阶段最小平方回归被用于与WHR密切相关的遗传变异.
- 使用遗传风险得分和两个样本MR (反变异加权方法) 来证实结果.
主要成果:
- 有证据表明,女性的WHR和CAD风险之间存在因果关系 (OR = 1.16 [1.06-1.26]).
- 在男性中没有发现WHR和CAD风险之间的统计学上显著的因果关系 (OR = 1.40 [0.98-2.01]).
- 在多种MR方法学中,研究结果一致.
结论:
- 在女性中,WHR是冠状动脉疾病的因果风险因素.
- 目前的证据不支持WHR在男性CAD风险中的因果作用.
- 未来的研究应该使用因果推理来探索性别特异性疾病机制.
关键词:
在这里,我们可以看到CAD,CAD,CAD.这就是为什么MR MR MR.门德尔的随机化身体脂肪组成 身体脂肪组成冠状动脉疾病是一种冠状动脉疾病.性别特定的性别特定的性别.腰与部周长的比例是腰与部周长的比例.更多相关视频
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