在接受多塞塔克塞尔的抗割前列腺癌男性中,现实世界治疗模式
Keith L Davis1, Benjamin Gutierrez2, Teresa Zyczynski3
1RTI Health Solutions, Research Triangle Park, NC, USA.
Journal of health economics and outcomes research
|September 4, 2023
概括
多塞塔克塞尔与普得尼松是治疗割抵抗性前列腺癌 (CRPC) 的常见治疗方法. 然而,治疗延迟和周期数量的变化表明了改善患者护理的潜在领域.
科学领域:
- 在瘤学瘤学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 临床实践研究 临床实践研究
背景情况:
- 自2004年以来,多塞塔克塞尔是美国用于治疗抗割前列腺癌 (CRPC) 的标准治疗方法.
- 关于dcetaxel在日常实践中的实际使用模式的数据有限.
研究的目的:
- 为了调查美国CRPC患者的多塞塔克塞尔使用模式.
- 分析患者的人口统计,治疗方案和停止治疗的原因.
主要方法:
- 在2004年至2010年期间接受治疗的394名CRPC患者的医疗记录的回顾性审查.
- 通过基于互联网的病例报告表格从瘤学和泌尿病学实践中收集的数据.
- 评估患者的特征,多塞塔克塞尔疗法细节和并发疗法.
主要成果:
- 大多数患者开始使用多塞塔塞尔与普雷尼松 (78.9%).
- 有关四分之一的患者在CRPC诊断后6个月或更晚开始服用多塞塔塞尔.
- 治疗持续时间各不相同,只有10%的患者接受了10个或更多的治疗周期.
结论:
- 多西和普得尼松是CRPC首选的一线治疗方案,与指南保持一致.
- 延迟启动和可变的治疗持续时间突出了优化CRPC管理的潜在领域.
- 需要进一步的研究,以了解延迟开始使用多塞塔克塞尔的原因和不同暴露时间的原因.
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