扩展复合质量评分 (CQS-2) 的评级者间可靠性
Steffen Mickenautsch1,2,3, Stefan Rupf4, Ivana Miletić5
1Faculty of Dentistry, University of the Western Cape, Bellville, South Africa.
Frontiers in medicine
|September 4, 2023
概括
复合质量评分-2 (CQS-2) 显示了非常高的评分间可靠性,与原来的CQS-1相比. 这表明CQS-2是评估临床试验的一个有希望的工具.
科学领域:
- 临床试验方法论 临床试验方法论
- 生物统计学 生物统计学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 评估临床试验报告的质量对于基于证据的医学至关重要.
- 综合质量评分 (CQS) 是用于此评估的工具.
- CQS-2是CQS的修订版本,旨在潜在地改进原来的CQS.
研究的目的:
- 为了确定复合质量评分-2 (CQS-2) 的评级者间可靠性.
- 为了比较CQS-2与第一个版本CQS-1之间的可靠性,CQS-1.
- 测试假设CQS-2的可靠性与CQS-1的可靠性没有显著差异.
主要方法:
- 四位独立评价者评估了45份临床试验报告,使用CQS-1和CQS-2.
- 评级者对彼此的评价是盲目的.
- 使用布伦南-普雷迪格系数 (BPC) 量化了评价者之间的可靠性.
- 采用两份样本的z测试来比较两个CQS版本的BPC.
主要成果:
- 对于CQS-1的BPC为0.85,表明了高的评价者间可靠性.
- CQS-2的BPC为1.00,表明了非常高的评价者间可靠性.
- 在CQS-1和CQS-2之间的可靠性差异在统计学上并不显著 (p=0.17).
- 零假设被接受了.
结论:
- CQS-2表现出非常高的间可靠性,与CQS-1相当.
- 这些发现支持继续开发和验证CQS-2.
- CQS-2显示出作为未来临床治疗试验的有价值评估工具的潜力.
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