骨消化性骨病变作为成人急性淋巴细胞白血病的初始表现:一个迷你回顾
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Abdulrahman F Al-Mashdali1, Hussam N Al-Dubai1, Mohamed A Yassin2
1Department of Oncology, Hematology and BMT Section, National Center for Cancer Care and Research, Hamad Medical Corporation.
Annals of medicine and surgery (2012)
|September 4, 2023
概括
在急性淋巴细胞白血病 (ALL) 中很少看到骨解质性骨病变. 这项对15例病例的审查发现骨疼痛和高血症是常见的,但预后意义仍然不清楚.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 骨生物学 骨生物学
背景情况:
- 血液性恶性瘤通常会导致骨损伤,特别是多发性骨髓瘤中的骨解损伤.
- 在各种白血病和淋巴瘤中,包括急性淋巴细胞白血病 (ALL) 中, osteolytic 骨损伤很少被报告.
研究的目的:
- 审查和描述急性淋巴细胞白血病 (ALL) 和骨解性骨损伤的发展之间的联系.
- 分析ALL和骨解性骨病变患者的临床特征,诊断方法和结果.
主要方法:
- 对急性淋巴细胞白血病 (ALL) 患者骨解质性骨病变的已发表病例报告的系统审查.
- 数据提取包括患者人口统计,ALL亚型,临床表现,诊断成像和治疗结果.
主要成果:
- 在所有患者中发现了15例骨解性骨病变,主要是男性 (平均年龄29岁).
- B细胞ALL是最常见的亚型;骨疼痛和高血症 (80%) 是经常出现的症状.
- 轴骨主要受到影响,成像方式包括放射,CT,MRI和PET扫描.
- 没有发现与费城染色体的关联,在成年人中没有报告脊髓压缩病例.
结论:
- 在ALL中,骨解性骨损伤很少见,但与特定的临床特征有关,如骨疼痛和高血症.
- 虽然大多数患者通过化疗实现了缓解,但ALL中这些病变的预后值需要进一步调查.
- 根据目前的病例报告数据,骨解质性骨病变的存在似乎并不表明更具侵略性的ALL形式.
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