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在非功能性胰腺神经内分泌瘤 (NF-PNET) 中的低血糖症:进一步了解一个未被认可的实体
Esther Osher1, Ravit Geva2, Ido Wolf2
1Institute of Endocrinology, Metabolism, and Hypertension, Tel Aviv-Sourasky Medical Center, Faculty of Medicine, Tel Aviv University, Israel.
Journal of clinical & translational endocrinology
|September 4, 2023
概括
非功能性胰腺神经内分泌瘤 (NF-PNETs) 经常与糖尿病 (DM) 和糖尿病前期 (DM前期) 相关. 葡萄糖代谢受损的这种高患病率与肥胖或瘤大小无关,因此需要提高临床意识.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 胰腺神经内分泌瘤 (PNETs) 的发病率正在上升,但与非功能性PNETs (NF-PNETs) 中的糖尿病 (DM) 和糖尿病前期 (Pre-DM) 的关联尚未确定.
- 虽然DM与其他胰腺疾病有关,但其与NF-PNETs的特定关系需要进一步描述.
研究的目的:
- 调查NF-PNET和DM/前DM之间的关联.
- 在NF-PNET患者中描述这种关联的临床特征.
主要方法:
- 一项回顾性研究评估了129名经组织学证实NF-PNETs患者队列中PRE-DM/DM的患病率.
- 分析了葡萄糖代谢,患者人口统计和瘤特征的数据.
主要成果:
- 70%的患者在治疗前呈现出异常的葡萄糖代谢 (34%的DM,36%的DM前).
- 在随访期间,DM/前DM的总体患病率增加到80.6%,主要是由于治疗后新诊断的DM.
- 患有DM/Pre-DM的患者年龄较大,瘤更频繁地位于胰腺体和尾部;BMI和瘤大小相似.
- 在NF-PNET患者中,DM的相对患病率是以色列一般人口的1.6倍.
结论:
- 很大一部分患有NF-PNET的患者表现出葡萄糖代谢受损 (DM或PRE-DM).
- 这种关联独立于肥胖和瘤大小.
- 在介绍和治疗NF-PNETs期间,临床医生应保持对DM的高度认识.
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