增加的呼气流量可以识别早期的间歇性肺病.
Sami Mohammed Alyami1, Onofre Moran-Mendoza2
1Department of Medicine, Division of Pulmonology, King Abdulaziz Medical City, Riyadh, Saudi Arabia.
Annals of thoracic medicine
|September 4, 2023
概括
高排气流量,特别是1秒内强制排气量/强制生命能力 (FEV1/FVC),可能是间歇性肺病 (ILD) 和异常性肺纤维化 (IPF) 中最早出现的肺功能测试异常. 这一发现表明,简单的螺旋计可以帮助早期诊断.
科学领域:
- 肺部医学 肺部医学
- 呼吸系统生理学 呼吸系统生理学
背景情况:
- 间歇性肺部疾病 (ILDs) 通常伴有限制性呼吸系统缺陷.
- 一氧化碳的低扩散能力 (Dlco) 是一个早期指标,但需要专门的设备.
- 识别早期肺功能测试 (PFT) 异常对于及时诊断ILD至关重要.
研究的目的:
- 调查是否高排气流是患有异常性肺纤维化 (IPF) 和其他ILDs的患者中最早的PFT异常.
- 确定简单的螺旋计在检测早期ILD/IPF时的实用性.
主要方法:
- 分析了在2013-2017年间诊断的289例发生ILD病例的现实世界队列.
- 最初的PFT在正常强迫生命能力 (FVC),肺总容量 (TLC) 和Dlco.co.uk的患者中进行了检查.
- 评估了高排气流量 (FEV1/FVC,FEF25,FEF25-75,FEF75和峰值排气流量),并对肺气,呼吸道阻力和肥胖进行了调整.
主要成果:
- 在88名患者 (30%) 中,正常的FVC,TLC和Dlco,高FEV1/FVC是最常见的异常 (37%).
- 这种异常在非肥胖患者 (43%) 和没有肺气和正常气道阻力 (58%) 的患者中更为明显.
- 在88名被诊断为IPF的患者中观察到类似的发现.
结论:
- 升高的FEV1/FVC比率可以在早期疾病阶段识别ILD/IPF患者.
- 简单的螺旋测量可以促进早期诊断和ILD/IPF的治疗开始.
- 这种方法为早期检测提供了复杂的PFT的成本效益较高的替代方案.
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