炎症性瘤与炎症性囊相关并发症的风险增加有关:一个回顾性队列研究
Ronaldo Paolo Panganiban1,2, Alyssa Tuan3, Maxwell Hart4
1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Penn State Hershey Medical Center, Hershey, PA, USA.
Crohn's & colitis 360
|September 4, 2023
概括
在发生性结肠炎 (UC) 的患者中,皮肤质 (PG) 发生在接受囊-门缩 (IPAA) 手术的患者中,与更糟糕的结果有关. 开发PG增加了袋子故障的风险,突出了其预测价值.
科学领域:
- 胃肠病学 胃肠病学
- 结肠直肠手术 结肠直肠手术
- 皮肤病学 皮肤病学
背景情况:
- 炎症性肠病 (PG) 是一种罕见的中性友皮肤病,也是炎症性肠病 (IBD) 的已确定的肠外表现 (EIM).
- 在经过全方位切口切除和囊-门解剖 (TPC-IPAA) 手术后,PG对性结肠炎 (UC) 患者的临床影响尚不清楚.
研究的目的:
- 为了研究皮肤病 (PG) 对性结肠炎 (UC) 患者的结局的影响,这些患者已经接受了整体结肠切除术和囊-门解剖手术 (TPC-IPAA) 手术.
- 为了比较TPC-IPAA患者的囊袋相关并发症与没有PG.
主要方法:
- 通过使用卡尔利诺家族炎症性肠道和结肠直肠疾病生物库 (1998-2021) 的数据进行了回顾性研究.
- 参与者包括UC患者,他们被诊断为前结肠切除术,并接受了TPC-IPAA手术.
- 评估的结果包括囊,囊形成,狭窄和囊衰竭,比较了PG和没有PG的患者.
主要成果:
- 在357名TPC-IPAA患者中,10名患有PG. 群体之间的人口统计数据相似.
- 患有PG的患者表现出类似的口袋炎,但口袋的风险明显更高 (50%vs. 10%),门 (40%vs. 12%) 和类似克罗恩病的口袋 (70%vs. 15%).
- 在囊炎之前的PG发育是最终囊衰竭的强有力的预测因素 (OR:20.7,q=0.003).
结论:
- 在接受TPC-IPAA手术的UC患者中,PG的发展与不良袋结局有关.
- 在这种患者群体中,PG是囊失效的重要预测因素.
- 这些发现强调了在UC患者IPAA手术后对PG的监测的重要性.
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