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Updated: Jul 17, 2025

Genome Editing in Mammalian Cell Lines using CRISPR-Cas
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Genome Editing in Mammalian Cell Lines using CRISPR-Cas

Published on: April 11, 2019

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在CRISPR-Cas系统中,DnaQ通过一个时间依赖机制调解方向间距的获取

Dongmei Tang1, Tingting Jia2, Yongbo Luo2

  • 1Department of Urology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.

Innovation (Cambridge (Mass.))
|September 4, 2023
PubMed
概括

克里斯普尔-卡斯免疫力依赖于间隔器集成. 这项研究揭示了Cas4缺乏系统中的DnaQ外核酶如何去除原空间器相邻动机 (PAM) 并确定CRISPR适应期间的空间器方向.

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