在固体瘤中的上皮细胞粘附分子的临床病理学和预后价值:元分析
Peiwen Ding1,2, Panyu Chen3, Jiqi Ouyang4
1Department of Oncology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Frontiers in oncology
|September 4, 2023
概括
固体瘤中高EpCAM表达与较差的生存结果相关,特别是在胃肠道和头癌中. 对于这些瘤类型,EpCAM可以作为预后生物标志物.
科学领域:
- 在瘤学瘤学.
- 生物标志物研究 生物标志物研究
- 癌症干细胞生物学
背景情况:
- 恶性固体瘤显著影响预期寿命.
- 表皮细胞粘附分子 (EpCAM) 是癌症干细胞生物标志物,在大多数正常的表皮细胞和癌症中表达.
- 在固体瘤中EpCAM的预后和临床病理学意义需要进一步澄清.
研究的目的:
- 使用元分析分析,分析EpCAM在固体瘤中的临床病理和预后价值.
- 确定EpCAM过度表达和各种固体瘤的生存结果之间的关联.
主要方法:
- 在主要数据库 (PubMed,EMBASE,Web of Science,Cochrane,PMC) 进行了系统的文献搜索,截至2022年3月7日.
- 对57篇文章的元分析,包括14184个病例,以评估与临床病理特征和生存相关的EpCAM过度表达.
- 聚合危险比率 (HRs) 和赔率比率 (ORs) 计算以评估相关性.
主要成果:
- 在固体瘤中,高EpCAM表达与较差的整体存活率 (OS) 和无病存活率 (DFS) 显著相关.
- 具体来说,EpCAM过度表达与胃肠道瘤中更糟糕的OS和DFS以及头瘤中更糟糕的DFS相关.
- EpCAM表达与组织学等级有关,但与性别,T分类,淋巴结转移,远程转移,血管透或TNM阶段无关.
结论:
- 过度表达EpCAM是固体瘤预后不佳的重要指标,特别是胃肠道和头癌.
- EpCAM表达与组织学等级相关,这表明它在瘤攻击性中的作用.
- EpCAM显示出作为胃肠道和头部瘤的预后生物标志物的潜力.
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