医疗保健资源利用和与自体主导多囊性病相关的成本
Christopher M Blanchette1, Şerban R Iorga2, Aylin Altan2
1Otsuka America Pharmaceutical, Inc., Princeton, NJ, USA; University of North Carolina, Charlotte, NC, USA.
Journal of health economics and outcomes research
|September 4, 2023
概括
自体主导多囊性病 (ADPKD) 的医疗费用很大,在慢性病 (CKD) 阶段显著增加. 从CKD第三阶段到第四阶段的进展显示出大幅增加的成本,主要是由于进展到末期病 (ESRD).
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 卫生经济学 卫生经济学
- 公共卫生 公共卫生
背景情况:
- 自体主导多囊性病 (ADPKD) 是一种遗传性病,导致末期病 (ESRD).
- 了解ADPKD的经济负担对于资源分配和患者管理至关重要.
研究的目的:
- 为了评估现实世界的医疗保健资源利用和成本在ADPKD患者.
- 分析不同慢性病 (CKD) 阶段的成本概况.
- 为了比较商业保险 (COM) 和医疗保险优势 (MAPD) ADPKD患者之间的成本.
主要方法:
- 来自Optum研究和影响国家基准数据库 (2006-2012) 的ADPKD患者的回顾性分析.
- 纳入标准: ≥30天连续益处,≥2个ADPKD索赔,没有自身逆性多囊性脏病.
- 基于血清肌素或透析代码的CKD分期;使用回归模型预测4年成本.
主要成果:
- 分析包括4356名COM和468名MAPDADPKD患者.
- 随着CKD进展 (1-5阶段) 医疗保健费用大幅增加.
- 预测的四年成本从40,164美元 (第一阶段) 到207,548美元 (第五阶段),从第三阶段到第四阶段的成本增加了348%.
结论:
- 无论保险类型如何,ADPKD都会产生大量的医疗保健费用和资源使用.
- 慢性瘤阶段是成本的主要驱动因素,其中88%归因于ADPKD和透析.
- 在CKD第3阶段和第4阶段之间发生了显著的成本升级,表明即将到来的ESRD和更高的未来成本.
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