患者对慢性髓性白血病药物治疗方案特征的偏好及其对坚持治疗方案的潜在影响:多国联合研究的结果
Ishan Hirji1, Jessica Grinspan2, Emuella Flood2
1Bristol-Myers Squibb, Wallingford, CT, USA.
Journal of health economics and outcomes research
|September 4, 2023
概括
患有慢性髓性白血病 (CML) 的患者重视方便的治疗方案. 饮食限制显著影响了坚持,首选的是每天服用一次剂量. 医疗保健提供者应考虑方便性,以改善药物坚持.
科学领域:
- 血液学 血液学 血液学
- 药物经济学 药物经济学
- 患者的坚持 患者的坚持
背景情况:
- 氨酸激酶抑制剂 (TKIs) 改善了慢性髓性白血病 (CML) 的存活率.
- 长期的TKI治疗需要方便的治疗方案,以确保患者的坚持.
- 由于复杂的治疗方案要求而导致的不遵守是CML管理中报告的一个问题.
研究的目的:
- 量化患者对方便的CML治疗方案的偏好.
- 评估治疗方案特征对药物坚持的影响.
- 为了确定患者愿意为更方便的治疗选择支付费用.
主要方法:
- 在六个国家进行的横截面研究,使用基于网络的离散联合实验 (DCE).
- 参与者评估了假设的治疗方法,其不同的是饮食要求,剂量频率和共同支付.
- 多项式逻辑模型推导了属性重要性;估计了支付意愿.
主要成果:
- 餐点要求/限制是最关键的属性,几乎是剂量频率的两倍.
- 患者表现出强烈的偏好,每天服用一次剂量,无论是与食物一起服用还是不服用.
- 服用药物前/后的禁食要求被认为是错过剂量的最可能原因.
结论:
- 在CML治疗方案中,患者评估的方便性是显著的.
- 与饮食相关的限制是影响药物服药的关键因素.
- 医疗保健提供者必须承认治疗方便在坚持治疗中的作用,并参与患者的公开沟通.
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