胃癌发病率基于内镜胃炎的京都分类
Osamu Toyoshima1, Toshihiro Nishizawa2, Shuntaro Yoshida1
1Department of Gastroenterology, Toyoshima Endoscopy Clinic, Tokyo 157-0066, Japan.
高的京都总分,表明晚期胃炎,显著增加了胃癌 (GC) 的风险. 内镜性胃炎评估有效地分层了监测GC风险.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 使用胃炎内镜发现的胃癌 (GC) 风险分层需要进一步调查.
- 京都胃炎分类提供了一个标准化的内镜评估.
研究的目的:
- 在内镜监测队列中分析胃癌 (GC) 的发生率.
- 通过时间到事件分析评估京都分类分数与GC发展之间的关联.
主要方法:
- 对6718名患者进行了回顾性研究,这些患者至少接受了两次食道胃管腺镜检查.
- 基于京都分类得分 (缩,肠道转化,扩大的,结节,扩散的红色,总得分) 确定了GC发生率.
- 考克斯危险模型用于计算GC开发的调整危险比率 (HR).
主要成果:
- 在长达2.56年的中位数随访期间,发生了34例GC病例 (年发病率为0.19%).
- 缩,肠道代谢,扩大的和扩散的红色的较高得分与增加的GC风险有显著的关联.
- 总京都分数为4或更高 (HR:6.23-16.45) 强烈预测了GC发展,每次排名上升都与1.75倍的风险相关.
结论:
- 较高的总京都评分 (≥4) 是胃癌发病率的重要预测指标.
- 通过京都分类对内镜性胃炎的评估是监测计划中胃癌风险分层的一个有价值的工具.
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