过量服用通道阻塞剂的治疗方法:系统性审查
Himanshi Baid1, Nidhi Kaeley1, Shiana Singh1
1Department of Emergency Medicine, All India Institute of Medical Sciences, Rishikesh, Rishikesh, IND.
Cureus
|September 4, 2023
概括
通道阻断剂中毒需要不同的治疗方法. ,高剂量胰岛素和其他疗法在改善结果和降低中毒病例死亡率方面表现有前途.
科学领域:
- 毒理学 毒理学 毒理学
- 心脏病学 心脏病学
- 紧急医疗 紧急医疗
背景情况:
- 通道阻塞 (CCB) 中毒是一种常见且严重的临床表现.
- 现有的文献缺乏针对CCB中毒的标准化治疗方案.
- 危及生命的并发症需要有效的管理策略.
研究的目的:
- 评估各种治疗方法对通道阻断剂中毒的疗效.
- 评估不同治疗对死亡率和血液动力学参数的影响.
- 审查二次结局,包括住院和ICU住院,血管压缩剂使用和功能结局.
主要方法:
- 在Ovid,PubMed,Cochrane图书馆和谷歌学者 (2014年1月 - 2022年12月) 进行了全面的文献搜索.
- 两位审查员选了607篇文章,包括18个案例报告,1个案例系列和1个队列研究.
- 数据提取的重点是死亡率,血液动力学稳定性和其他临床结果.
主要成果:
- 经常使用糖/,通常与多巴胺和上腺素等血管压缩剂一起使用,与较低的死亡率有关.
- 高剂量胰岛素治疗改善了血液动力学和降低了死亡率,尽管存在低血糖和低血糖的风险.
- 静脉输入的脂质乳液,体外生命支持,葡萄糖,甲蓝,专蛋白和特里普林素与改善的结果有关.
结论:
- 多种治疗方式,包括,高剂量胰岛素和先进疗法,可以改善通道阻断剂中毒的结果.
- 需要进一步的研究来建立统一的治疗方法.
- 从审查的病例报告中没有获得长期末端器官损伤数据.
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