在HER2阳性乳腺癌中成功接受新辅助治疗的预测因素
Elli-Noora Hännikäinen1, Johanna Mattson1, Peeter Karihtala1
1Department of Oncology, Helsinki University Hospital Comprehensive Cancer Centre and University of Helsinki, FI-00029 Helsinki, Finland.
Oncology letters
|September 4, 2023
概括
在新辅助疗法 (NAT) 后的病理完整反应 (pCR) 是HER2阳性乳腺癌中优秀无病生存的强有力的预测指标. 适度的HER2表达表明pCR的可能性较低,生存率更差.
科学领域:
- 在瘤学瘤学.
- 乳腺癌研究研究 乳腺癌研究
- 分子诊断学 分子诊断
背景情况:
- 在新辅助疗法 (NAT) 后,HER2阳性乳腺癌的预后通常是很好的.
- 然而,一小部分患者仍然经历疾病进展,需要识别新的预测因素.
- 分析了当前的治疗方案和患有大型原发性瘤和淋巴结转移的患者队列.
研究的目的:
- 在接受NAT的HER2阳性乳腺癌患者中确定治疗反应和生存的预测因素.
- 评估病理完整反应 (pCR) 和HER2表达水平的预后意义.
主要方法:
- 对119名HER2阳性乳腺癌患者的回顾性分析,这些患者接受了NAT治疗.
- 使用in situ杂交方法确认HER2状态.
- 评估病理完整反应 (pCR) 和放射性完整反应 (CR).
- 免疫组织化学HER2表达水平的评估.
主要成果:
- 52.1%的患者实现了pCR,这显著预测了更长的无病生存期 (DFS).
- 放射性CR与pCR相关,但具有显著的假阴性和假阳性率.
- 适度的免疫组织化学HER2表达与PCR的可能性较低和乳腺癌特异性生存率较低有关.
结论:
- 在NAT之后的pCR是高风险HER2-阳性乳腺癌的关键预后指标.
- 具有中度HER2表达的患者实现pCR的机会降低,并面临更糟糕的生存结果.
- 对HER2阳性乳腺癌的预测标志物的进一步研究是有必要的.
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