在乳腺癌中使用预后值对ACKR家族成员的综合分析
Lixian Yang1, Shiyu Zhang1, Pengpeng Pu1
1Department of Breast Surgery, Xingtai People's Hospital, Xingtai, Hebei 054000, P.R. China.
Oncology letters
|September 4, 2023
概括
非典型的化学因受体 (ACKR) 在乳腺癌中表现出改变的表达和甲基化,影响患者的存活率. 这些受体与免疫细胞透有关,这表明它们可能是乳腺癌治疗的预后指标.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 遗传学 是一个遗传学.
背景情况:
- 乳腺癌 (BC) 是女性的主要恶性瘤.
- 非典型的化学因受体 (ACKR) 是G蛋白合受体,在BC中作用不明.
- 之前的研究报告了在BC中对ACKR的一些发现.
研究的目的:
- 研究乳腺癌 (BRCA) 中ACKRs的表达和甲基化模式.
- 为了确定在BRCA患者中ACKR表达的预后意义.
- 探索ACKR表达和BRCA免疫细胞透之间的关系.
主要方法:
- 利用了瘤免疫估计资源,UALCAN和基因表达概况交互分析数据库.
- 分析了BRCA与正常组织中的ACKR表达水平和促进物甲基化.
- 与远程转移无生存率 (DMFS),总生存率 (OS) 和无复发生存率 (RFS) 相关联的ACKR表达.
主要成果:
- 与正常组织相比,BRCA组织中的ACKR表达显着较低.
- 在BRCA中观察到ACKR1,ACKR3,ACKR5的低甲基化和ACKR2,ACKR6促进者的高甲基化.
- ACKR1,ACKR2,ACKR3,ACKR4和ACKR6的表达水平与患者生存结果 (DMFS,OS,RFS) 有显著的关联.
- ACKR表达与诸如树突细胞,巨细胞,中性粒细胞和T细胞 (CD4+,CD8+) 等免疫细胞的透相关.
结论:
- 在乳腺癌中,ACKR表达和甲基化发生变化.
- ACKRs作为BRCA的潜在预后生物标志物.
- ACKRs可能代表乳腺癌的新疗法标,可能通过调节瘤免疫微环境.
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