抗微生物FiteBac® K21促进抗微生物功效和伤口愈合
Ranjeet Ajit Bapat1, Rikan Libat1, Ong Shu Yuin1
1Restorative Division, School of Dentistry, International Medical University Kuala Lumpur, 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000, Wilayah Persekutuan Kuala Lumpur, Malaysia.
Heliyon
|September 4, 2023
概括
一种新的四级氨基 (QAS/K21) 根管灌剂有效地消除了细菌生物膜,并在体内减少了炎症. K21显示了抗微生物特性,促进了组织修复,显示了内牙治疗的潜力.
科学领域:
- 牙周内学和牙科材料科学 牙科材料科学
- 微生物学和免疫学
背景情况:
- 根管治疗的成功取决于牙中生物膜的完全消除.
- 目前的灌者在根除持久的根管生物膜方面面临着挑战.
研究的目的:
- 评估一种新型四级氨基 (QAS/K21) 灌剂的抗菌膜和抗菌疗效.
- 评估K21在体内对*Fusobacterium nucleatum*和*Enterococcus faecalis*生物膜的抗炎作用.
主要方法:
- 福利埃变换红外光谱法 (FTIR) 和拉曼光谱法分析了K21的组成.
- 在根性牙上的生物膜被K21,NaOCl,CHX或盐水处理.
- 扫描电子显微镜 (SEM),传输电子显微镜 (TEM),以及对老鼠的体内研究评估了生物膜透,细胞效应和炎症.
主要成果:
- K21证明了细菌细胞壁的透和膜破坏.
- SEM显示了0.5%K21的显著树脂标签形成,表明牙透.
- 在体内,K21最初引起了刺激,但随着CD68表达的增加和M2巨细胞的偏离,引起了刺激,这表明了抗炎作用的潜力.
结论:
- K21表现出强大的抗菌膜和抗菌活性,有效地穿透细菌壁.
- K21显示为治疗效益的根管灌剂的承诺.
- 抗炎性质和M2极化表明K21可以帮助解决炎症并促进组织修复.
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