如何选择外细胞矩阵用于伤口修复:全面的审查
Samuel Stetkevich1, Monik Gupta2, Richard Simman3,4
1Department of Medicine, UCLA-Oliveview Medical Center, Sylmar, California.
Eplasty
|September 4, 2023
概括
这篇评论比较了外细胞矩阵 (ECM) 的伤口愈合,发现无细胞化鱼皮 (AFS) 提供了优越的愈合和化品的结果,尽管可访问性挑战. 生物工程矩阵和异种移植提供了具有抗微生物特性的良好替代品.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 伤口护理 伤口护理
背景情况:
- 细胞外矩阵 (ECM) 产品自1930年以来一直在发展,以改善伤口愈合,最大限度地减少痕和减少疼痛.
- 目前,医生对ECM的选择是基于经验和患者特定因素,缺乏全面的比较数据.
- 需要进行彻底的调查,比较大多数可用ECM的伤口愈合效果.
研究的目的:
- 进行文献审查,以确定最佳的外细胞矩阵 (ECM) 创伤愈合和积极的患者结果.
- 为了比较各种ECM的指示,优点和缺点,以指导临床选择.
- 在伤口护理中提供基于证据的ECM选择方法.
主要方法:
- 使用PubMed数据库进行了文献综述,分析了71篇文章.
- 主要的搜索术语包括"细胞外基质"",异种移植"",异种移植"",生物工程基质"",非细胞化鱼皮"",伤口愈合".
- 该审查侧重于临床试验,病例系列和其他评论文章,评估受欢迎的ECM.
主要成果:
- 整体移植是合适的,但在愈合速度和质量方面低于生物工程基质,猪/牛异种移植和非细胞化鱼皮 (AFS).
- 生物工程矩阵和异种移植提供抗菌性质,低免疫性和成本效益,但在愈合时间和宇宙中存在局限性.
- AFS表现出优越的愈合时间和化品效果,具有抗微生物和低免疫性益处,尽管可访问性和成本是潜在的缺点.
结论:
- 本综述为ECM选择提供了指南,减少了临床决策中的主观性.
- 建议进行进一步的对头试验,以开发一种更算法化的伤口愈合选择方法.
- 建议在未来的试验中实施客观措施,例如手臂,肩膀和手的残疾 (DASH) 评分.
相关概念视频
Phases of Wound Repair
6.1K
Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
6.1K
The Extracellular Matrix
9.1K
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
9.1K
Extracellular Matrix
2.9K
Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
2.9K
Role of Matrix Metalloproteases in Degradation of ECM
2.4K
Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult...
2.4K
Overview of Cell-Matrix Interactions
7.3K
The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
7.3K
Cell-matrix's Response to Mechanical Forces
2.7K
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue.
Anchoring junctions mechanically attach a cell to the...
Anchoring junctions mechanically attach a cell to the...
2.7K


