胆管癌中非编码RNA:一个更新
Jiehan Li1, Haolin Bao1, Ziyue Huang1
1Hepatopancreatobiliary Surgery, Second Affiliated Hospital of Harbin Medical University, 150086 Harbin, Heilongjiang, China.
Frontiers in bioscience (Landmark edition)
|September 4, 2023
概括
胆管癌 (CCA) 的进展受到非编码RNA (ncRNA) 的影响. 了解长非编码RNAs (lncRNAs) 和循环RNAs (circRNAs) 的机制为这种侵袭性癌症提供了新的诊断和治疗策略.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 胆管癌 (CCA) 是一种高度恶性且越来越常见的癌症.
- 晚期诊断和转移导致患者的生存率低下.
- 识别新的生物标志物和治疗点对于改善CCA结果至关重要.
研究的目的:
- 审查长非编码RNAs (lncRNAs) 和圆形RNAs (circRNAs) 在CCA进展中的分子机制.
- 讨论这些非编码RNA在CCA诊断和治疗中的潜在临床应用.
主要方法:
- 关于CCA中lncRNAs和circRNAs的最近研究的文献综述.
- 分析了ncRNA在CCA病变发生中的调节作用.
- 对生物标志物和治疗点的临床相关性评估.
主要成果:
- 异常表达的lncRNAs和circRNAs显著调节了CCA的发育.
- 这些ncRNAs通过表观遗传修饰,miRNA海绵和信号通路调制来起作用.
- 特定的lncRNAs和circRNAs作为诊断和预后生物标志物非常有前途.
结论:
- lncRNA和circRNA是CCA分子机制中的关键参与者.
- 针对这些ncRNAs为CCA提供了新的治疗机会.
- 进一步的研究可以将这些发现转化为临床实践,以改善患者护理.
相关概念视频
02:39lncRNA - Long Non-coding RNAs
8.6K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.6K
02:57Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K