对于患有亚托皮性皮肤炎的儿科患者的生物制剂:实际挑战和知识差距
Lisa P van der Rijst1,2, Annet van Royen-Kerkhof3, Suzanne G M A Pasmans4,5
1Department of Dermatology and Allergology, University Medical Center Utrecht, Wilhelmina Children's Hospital, Utrecht, the Netherlands.
The Journal of dermatological treatment
|September 4, 2023
概括
生物疗法为幼儿中度至重度的亚托皮炎 (AD) 提供了新的希望. 然而,在婴儿和学龄前儿童中实施这些治疗方法存在实际挑战和知识差距.
科学领域:
- 儿科皮肤学 儿科皮肤学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 生物疗法,如dupilumab和tralokinumab,对于治疗儿童中度至重度亚托皮炎 (AD) 的治疗越来越重要.
- 杜皮卢马布是第一个被批准用于儿科阿尔茨海默病患者的生物药物,现在包括6个月至5岁的儿童.
研究的目的:
- 讨论当前的实际挑战和知识差距,涉及婴儿和学龄前儿童 (六岁以下) 中度至重度亚托皮炎的生物治疗的实施.
- 为解决这个脆弱人群中对有效和安全的治疗选择的未满足需求.
主要方法:
- 审查当前的文献和临床指导方针对儿童亚托邦性皮肤炎的生物治疗方法.
- 分析实用方面,包括治疗开始,停止和长期使用皮下注射.
- 识别关于长期影响,对并发病的影响和活体减弱疫苗的知识差距.
主要成果:
- 关于在婴儿和学龄前儿童中实践实施AD的生物制剂的数据有限.
- 关于长期安全性,对伴随疾病的影响以及对活体减弱疫苗的影响,知识缺口仍然存在.
- 随着从6个月开始对阿尔茨海默病的生物药物的引入,可能会出现潜在的挑战.
结论:
- 需要进一步的研究和实际指导,以优化在患有AD的婴儿和学龄前儿童中使用生物制剂.
- 解决实施挑战对于这个年龄组的安全有效的生物疗法至关重要.
- 了解长期结果和安全概况对于广泛采用至关重要.
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