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Updated: Jul 17, 2025

Analysis of DNA Double-strand Break DSB Repair in Mammalian Cells
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Analysis of DNA Double-strand Break DSB Repair in Mammalian Cells

Published on: September 8, 2010

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ZEB1促进非同类末端连接的双链断裂修复

Thomas L Genetta1, Joshua C Hurwitz1, Evan A Clark1

  • 1Dept. of Radiation Oncology, University of Virginia School of Medicine, PO Box 800383, Charlottesville, VA 22908, USA.

Nucleic acids research
|September 4, 2023
PubMed
概括

转录抑制剂ZEB1与53BP1相互作用,调节DNA双链断裂 (DSB) 修复. 这种相互作用影响同源重组,使BRCA1缺乏细胞对PARP抑制剂产生敏感性.

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