不同症状反流性食道炎治疗方法的比较:一个现实世界的研究
Francesco Di Mario1, Pellegrino Crafa1, Lorella Franzoni1
1Department of Medicine and Surgery, University of Parma, Italy.
概括
质子抑制剂与粘膜保护药物相结合,可以有效地缓解GERD症状. 在这项研究中,prokinetics显示了更高的治疗失败率和更多副作用.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
- 临床治疗学 临床治疗学
背景情况:
- 质子抑制剂 (PPI) 是标准的GERD治疗,但症状复发很常见.
- 作为PPI的辅助剂,原动力学或屏障药物的比较有效性受到争议.
研究的目的:
- 评估胃食道逆流性疾病 (GERD) 的各种治疗策略的有效性.
- 为了比较单独的PPI,粘膜保护药物, prokinetics,屏障药物和组合.
主要方法:
- 一个非随机的,开放的标签试验,涉及211名患有A级反流食道炎的患者.
- 六个连续的2个月的治疗方案与3周的洗期进行.
- 治疗包括PPI (easomprazole),粘膜保护剂, prokinetics,屏障药物和组合;通过VAS和GSS评估症状.
主要成果:
- 大多数治疗方法显著改善了视觉模拟量表 (VAS) 和全球症状评分 (GSS).
- 与PPI和粘膜保护药物 (E组) 的联合治疗显示出最显著的GSS改善.
- 促性单疗法 (C组) 和障碍药单疗法 (D组) 显示出有限的疗效,而C组具有较高的学率和副作用.
结论:
- 将质子抑制剂 (PPI) 与粘膜保护药物相结合,可以显著缓解GERD的症状.
- 单独使用的促动剂与治疗失败和不良事件的增加有关.
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