在一个大型学术中心的儿科输血依赖性沙拉西米亚患者的表征
Dorsa Zarrabian1, Mirette Hanna1,2,3
1Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.
Journal of clinical laboratory analysis
|September 4, 2023
概括
接受ABO,RhD和K匹配血液的输血依赖性沙拉西米亚患者的同免疫率较低. 延长Rh抗原匹配可能会进一步减少儿科患者的免疫接种.
科学领域:
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
- 儿科 儿科 儿科
背景情况:
- 输血依赖性沙拉西米亚患者面临高风险的输血并发症.
- 关于儿科患者与免疫接种频率的数据有限.
- 没有关于预防性抗原匹配的共识,对于血病患者.
研究的目的:
- 评估小儿输血依赖性沙拉血病患者的免疫接种频率和特异性.
- 调查患者特征与免疫接种之间的关联.
- 为了评估ABO,RhD和K匹配红细胞输血的有效性.
主要方法:
- 对输血依赖性沙拉西米亚患者的回顾性研究 (2018年7月 - 2022年6月).
- 审查了临床和输血记录.
- 评估了针对特定血型抗原的免疫.
主要成果:
- 9% (8/92) 的患者产生了临床显著的alloantibodies.
- 6%的人产生了抗E抗体,2%的人产生了多种抗体.
- 加拿大以外的输血,β-thalassemia诊断和自身抗体的发展与非免疫接种有关.
结论:
- ABO,RhD和K匹配减少了,但并没有消除免疫接种.
- 扩展Rh抗原匹配可以进一步降低所有免疫率.
- 对最佳抗原匹配策略的进一步研究是有必要的.
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