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Microfluidics in Assessing Platelet Function

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在稳定创伤患者中预测中期血小板输血使用旋转血小板造影仪

Ha Jin Lim¹, Hyunseok Jang², Naa Lee²

¹Department of Laboratory Medicine, Chonnam National University Medical School and Chonnam National University Hospital, Gwangju, Korea.

Annals of laboratory medicine

|September 4, 2023

概括

旋转血小板造影仪 (ROTEM) 参数,特别是FIBTEM和EXTEM,可靠地预测创伤患者中期血小板输血. 这些测试与传统的凝血标志物相关,有助于输血指导.

科学领域:

凝血诊断仪器凝血诊断仪器
创伤患者的管理管理.
输血药物输血药物输血药物

背景情况:

旋转血小板造影仪 (ROTEM) 是一种用于指导创伤患者血小板输血的全球凝血测试.
预测创伤患者中期血小板输血的需要对于有效管理至关重要.

研究的目的:

评估ROTEM参数对创伤患者中期 (五天) 血小板输血需求的预测能力.
评估ROTEM参数与传统凝血试验的相关性.

主要方法:

在82名住院创伤患者的复苏后ROTEM参数 (FIBTEM,EXTEM,PLTEM) 的回顾性分析.
分析了最大的凝块坚定度和凝块幅度 (A5,A10,A15).
血小板输血数据在ROTEM分析后的五天内被审查.

主要成果:

FIBTEM和EXTEM显示出高预测准确度 (AUC分别为0.915-0.923和0.878-0.896) 预测>12U血小板度输血.
PLTEM显示了中等的预测值 (AUC 0.551-0.735).
在血小板计数和EXTEM/PLTEM,血小板功能和EXTEM,纤维素水平和FIBTEM参数之间观察到强烈的相关性.

结论:

在创伤患者中,FIBTEM和EXTEM是预测中期血小板输血需求的可靠工具.
ROTEM参数与传统的凝血测试相关,包括血小板计数和纤维素素水平.

关键词:

纤维素原蛋白是一种纤维素.血小板输血输血血小板输血血小板是血小板的组成部分.旋转性血栓弹性测量 (Thromboelastometry) 是一种旋转式血栓弹性测量.创伤是一个创伤.

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