脊髓刺激对心血管的影响:高潮,低潮和不知道
Marco Law1, Rahul Sachdeva1, David Darrow2
1International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, BC, Canada; Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
Neuromodulation : journal of the International Neuromodulation Society
|September 4, 2023
概括
脊髓刺激 (SCS) 显示出心血管神经调节的潜力,特别是血压 (BP) 的变化. 然而,最佳的刺激部位和参数需要通过严格的临床试验进行进一步调查.
科学领域:
- 神经学 神经学
- 心血管科学 心血管科学
- 生物医学工程 生物医学工程
背景情况:
- 心血管控制障碍有多种来源,包括慢性压力和神经退行性疾病.
- 自1959年以来,脊髓刺激 (SCS) 已经被探索为调节血压 (BP),心率 (HR) 和心率变化 (HRV).
- 具体的SCS参数和有效心血管 (CV) 调制的解剖目标仍然不清楚.
研究的目的:
- 审查SCS的临床研究及其对心血管参数的影响.
- 调查SCS在心血管神经调节中的有效性和最佳参数.
主要方法:
- 在MEDLINE,Embase和PubMed数据库中进行了全面的文献搜索.
- 包括的研究涉及接受SCS的人类参与者,与非刺激条件相比,报告了心血管发现 (HR,BP,HRV).
- 数据被视觉分析,并对可用的刺激参数进行定量分析.
主要成果:
- 审查了59项研究,其中大多数使用侵入性SCS.
- 宫和胸脊SCS显示出增加和减少静止BP的潜力.
- SCS对HR和HRV的影响是不确定的,并且参数报告往往不足以进行详细分析.
结论:
- SCS代表了心血管神经调节的有希望的方法,特别是对BP调节.
- 进一步的大规模随机对照试验与详细的参数报告对于验证SCS作为心血管治疗至关重要.
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