利用台湾人口的面包消费估计,对索衍生物的饮食风险评估
Hsin-Chang Chen1, Chung-Jung Tsai2, Yu-Fang Huang3
1Department of Chemistry, College of Science, Tunghai University, Taichung, Taiwan.
Environmental science and pollution research international
|September 4, 2023
概括
芬 (BP) 和它的类似物 (BPs) 是食品中发现的内分泌干扰剂. 这项研究发现面包中含有BP,但人类食用面包的风险是安全的,所有年龄段人都可以接受.
科学领域:
- 环境化学环境化学
- 食品安全 食品安全
- 毒理学 毒理学 毒理学
背景情况:
- 类 (BPs) 是内分泌干扰化学物质和新兴污染物.
- 紫外线油墨可以从紫外线油墨中迁移到食物中,这引发了人们对人类暴露的担忧.
- 关于食品中的BP水平和相关的人体健康风险的数据有限.
研究的目的:
- 为了验证一种检测食品中的10种类 (BPs) 的方法.
- 评估面包中的BP对人类的暴露风险,包括非癌症和癌症风险.
- 为了评估七个不同年龄组的这些风险.
主要方法:
- 通过使用稳定同位素标记和UHPLC-ESI-MS/MS.验证了一种痕迹和多残留方法.
- 用固体液体提取方法分析了81个面包样本.
- 采用蒙特卡洛模拟来确定估计的每日摄入量,非癌症风险 (危险指数) 和终身癌症风险 (LTCR).
主要成果:
- 分析方法显示高线性 (R2 ≥0.991) 和低检测极限 (0.04-2 ng/g).
- 在面包样本中分别检测到97%-67%,59%,24%和23%的索 (BP),4-MBP,2-OHBP,BP-1和BP-3.
- 0-3岁的年龄组表现出最高的LTCR (2.6 × 10−6) 和HI (5.4 × 10−2),但所有值都保持在可接受的安全限度内.
结论:
- 经过验证的方法对于在食品矩阵中分析BP是可靠的.
- 通过食用面包消费对BP的饮食暴露不会对健康造成重大风险.
- 目前面包中的BP暴露水平被认为是安全的,并且可以接受所有年龄的人群.
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