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发现了基于天然黄酸盐的新型cGAS抑制剂

Jiameng Li1, Muya Xiong2, Jiayuan Liu3

  • 1School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Bioorganic chemistry
|September 4, 2023
PubMed
概括

天然黄酸盐贝卡林和贝卡林被确定为循环GMP-AMP合成酶 (cGAS) 的新型抑制剂,这是炎症的关键因素. 这一发现为开发针对cGAS的新抗炎疗法提供了有前途的途径.

关键词:
晶体结构 晶体结构循环GMP-AMP合成酶的使用黄类化合物 黄类化合物抑制剂的抑制剂虚拟选是一个虚拟的选.

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