多药耐药和多病毒性鸟类细菌病原体:利用单独或组合使用植物生物和抗生素解决实验性腿部疾病
Naglaa F S Awad1, Marwa I Abd El-Hamid2, Nehal M Nabil3
1Department of Avian and Rabbit Medicine, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Egypt.
Poultry science
|September 4, 2023
概括
耐多药细菌导致家禽腿部疾病,导致经济损失. 梅花精油与佛罗芬尼科尔或阿莫西西林/克拉夫兰酸等抗生素相结合,有效地治疗了和的这些疾病.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 微生物学 微生物学
- 动物科学动物科学
背景情况:
- 由多药耐药 (MDR) 细菌引起的家禽的机电障碍对全球家禽产业构成重大经济威胁.
- 对化学抗微生物药物的耐药性日益增加,需要探索替代疗法,特别是那些来自植物等自然来源的疗法.
研究的目的:
- 为了确定主要细菌病原体 (金黄色葡萄球菌,沙门氏菌种,Mycoplasma synoviae,大肠杆菌) 的流行率和抗菌素耐药性模式,在有运动问题的家禽中.
- 评估精油 (大黄,大,生,肉) 对MDR细菌分离物的体外抗菌疗效.
- 评估最有效的抗生素和精油单独或组合的体内治疗潜力,用于治疗试验诱导的家禽腿部疾病.
主要方法:
- 从500个表现出运动障碍的肉和子样本中进行细菌分离和鉴定.
- 抗微生物敏感性测试以确定多药性耐药性 (MDR) 的流行率.
- 在体外测试精油 (大黄,大,生,肉) 对MDR细菌分离物的检测.
- 使用实验诱导的禽类腿部疾病进行体内研究,以评估抗生素和精油的治疗疗效.
主要成果:
- 记录了黄金葡萄球菌 (54%),大肠杆菌 (48%),沙门氏菌 (36%) 和Mycoplasma synoviae (2%) 的高发病率.
- 在大多数分离物中,MDR普遍存在,其中Mycoplasma synoviae (100%),大肠杆菌 (91.7%),沙门氏菌 (81.1%),金黄色葡萄球菌 (78.5%) 显示出高耐药性.
- 梅花精油在体外表现出最强烈的活性,对抗MDR抗菌素耐药黄金葡萄球菌 (VRSA) 和沙门氏菌Typhimurium.
- 在体内,马乔兰与花尼科尔或阿莫西西林/克拉夫兰酸相结合,显著改善了治疗鸟类的临床和组织病理结果,降低了细菌负载.
结论:
- 梅花精油表现出强大的抗菌活性,对关键的家禽病原体.
- 马乔兰与花尼科尔或阿莫西西林/克劳兰酸的组合为禽类腿部疾病提供了一个有前途的治疗策略.
- 这种协同方法有可能减少家禽行业的抗生素使用,减轻对抗菌素耐药性的担忧.
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