与处方大麻二醇使用相关的治疗结果在开始后12个月
Kayla Johnson1, Jessica P Barnes2, Holly Dial2
1Vanderbilt Specialty Pharmacy, Vanderbilt Health System, 1211 Medical Center Dr, Nashville, TN 37232, USA.
Epilepsy & behavior : E&B
|September 4, 2023
概括
处方大麻 (CBD) 治疗导致37%的患者在12个月内使用显著的紧急医疗服务 (EHS). 由于副作用或缺乏反应,停止治疗是常见的,而抗发作药物 (ASM) 使用没有变化.
科学领域:
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 大麻 (CBD) 越来越多地被用于治疗.
- 处方CBD的现实世界结果对于临床实践至关重要.
研究的目的:
- 为了评估患者在12个月内处方大麻 (CBD) 的结果.
- 评估与有关的紧急医疗保健服务 (EHS) 的使用情况.
- 为了确定CBD停药率和原因,以及同时使用抗发作药物的变化.
主要方法:
- 一项前性队列研究包括136名从2019年1月到2020年4月处方CBD的患者.
- 主要结局:在12个月内使用相关的EHS.
- 二次结局:CBD停用,停用原因和同时使用ASM.
- 后勤回归分析了EHS使用几率,并对共变量进行调整.
主要成果:
- 37%的患者 (n=50) 使用了EHS,包括急诊室访问和住院.
- 第一次EHS遭遇的中位时间是ED访问的69天和住院的104天.
- 23%的患者 (n=31) 由于副作用或不满意的反应而停止使用处方CBD.
- 没有观察到与ASM同时使用的显著变化.
结论:
- 处方CBD治疗与第一年大量的EHS利用有关.
- 副作用和缺乏疗效是停止使用CBD的主要原因.
- 对于处方CBD的患者来说,临床监测至关重要,特别是在EHS使用和治疗坚持方面.
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