暴露于纳米塑料颗粒和哺乳动物细胞中的DNA损伤
Peter Møller1, Martin Roursgaard1
1Department of Public Health, Section of Environmental Health, University of Copenhagen, Øster Farimagsgade 5A, DK-1014 Copenhagen K, Denmark.
Mutation research. Reviews in mutation research
|September 4, 2023
概括
人类暴露在纳米塑料中的问题越来越严重. 研究表明,聚乙烯纳米塑料可能在哺乳动物细胞中引起基因毒性作用,特别是在免疫细胞中.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 材料科学 材料科学 材料科学
背景情况:
- 纳米塑料,颗粒<1000nm,引起了人们的担忧,因为通过环境退化和故意使用,人类暴露.
- 了解纳米塑料的基因毒性潜力对于人类健康风险评估至关重要.
研究的目的:
- 审查和评估纳米塑料的基因毒性影响,重点关注聚烯 (PS) 颗粒.
- 分析影响纳米塑料基因毒性的因素,包括粒子类型,大小和细胞敏感性.
主要方法:
- 对纳米塑料基因毒性研究的系统审查,主要使用哺乳动物细胞培养.
- 对基因毒性终点的分析,如DNA链断裂 (彗星测定) 和微核形成.
- 基于PS修饰,细胞类型,颗粒大小和终点的基因毒性影响的统计分析.
主要成果:
- 在60个结果中,有29个结果显示了细胞培养中PS暴露的显著基因毒性影响.
- 修改后的PS颗粒和免疫细胞对基因毒性的敏感性更高.
- 动物研究表明,PS暴露后白细胞和前额叶皮层细胞的DNA链断裂增加.
- 对于其他纳米塑料 (聚乙烯,聚烯,PVC,PET) 存在有限的数据,排除了最终结论.
结论:
- 聚乙烯纳米塑料在哺乳动物细胞中显示出基因毒性的证据.
- 免疫细胞似乎更容易受到纳米塑料诱导的基因毒性.
- 需要进一步的研究来评估各种纳米塑料的基因毒性危害.
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