相关实验视频

Updated: Jul 28, 2026

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

一种用于药物加载的水凝系统,用于减少剂/热敏药物的协同应用

Yucen Cai¹, Xiaoxue Fu², Yingjuan Zhou¹

¹Chongqing Key Laboratory for Pharmaceutical Metabolism Research, Chongqing Pharmacodynamic Evaluation Engineering Technology Research Center, College of Pharmacy, Chongqing Medical University, Chongqing 400016, PR China.

Journal of controlled release : official journal of the Controlled Release Society

|September 4, 2023

概括

这项研究引入了一种用于药物输送的新型水凝 (New-gel),克服了敏感药物的传统方法的局限性. 新凝提供了增强的药物加载,释放和治疗疗效,特别是在糖尿病伤口修复方面.

科学领域:

生物材料科学生物材料科学
聚合物化学聚合物化学
药物输送系统药物输送系统

背景情况:

对于水凝药物载体而言,基质介导的聚合是有希望的,但受到基质氧化和反应热的限制,影响敏感的药物负载.
由于恶劣的聚合条件,传统方法与减负剂/热敏药物作斗争.

研究的目的:

开发一种先进的水凝 (New-gel),使用一种新的酸辅助策略,以改善药物加载和协同治疗应用.
克服传统的激素介导水凝对于敏感药物输送的局限性.

主要方法:

通过基质介导的单体聚合合成一种功能性水凝 (New-gel),然后通过酸辅助的修饰与酸基组进行.
评估了New-gel的化学/物理特性,药物加载/释放动力学,以及糖尿病伤口修复模型中的治疗疗效.

主要成果:

与传统水凝相比,New-gel表现出优越的化学/物理性能,高效的药物加载/释放,并保持了药物活性.
在糖尿病伤口修复中获得了出色的氧气负载能力和显著的治疗效果.
新凝的高光透射度增强了光敏感药物的抗菌疗效.

结论:

开发的酸辅助凝策略为创建用于药物输送的先进水凝提供了一个多功能平台.
新凝具有重要的生物医学应用潜力,包括伤口愈合和协同光动力学疗法.

关键词:

糖尿病的伤口水凝是一种水凝.充满氧气的装载降低剂/热敏药物降低剂/热敏药物协同作用的应用程序协同作用

更多相关视频

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

相关概念视频

Modified-Release Drug Delivery Systems: Rate-Programmed II

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...

Modified-Release Drug Delivery Systems: Stimuli-Activated

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...