高温加剧臭氧引起的气道炎症:气道微生物群和代谢物的影响
Fei Xu1, Qiong Wu1, Yishu Yang1
1School of Public Health, Xinxiang Medical University, Xinxiang, China.
The Science of the total environment
|September 4, 2023
概括
高温 (HT) 暴露会使臭氧 (O3) 诱导的呼吸道炎症和氧化应激在小鼠中恶化. 这种恶化与肠道微生物群的变化和呼吸道代谢功能障碍有关.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 微生物学 微生物学
背景情况:
- 短期暴露于臭氧 (O3) 与呼吸道炎症有关.
- 高温 (HT) 加快了O3的产生,引发了人们对组合效应的担忧.
- 调查HT和O3同时暴露对呼吸系统健康的影响至关重要.
研究的目的:
- 为了确定高温 (HT) 是否会加剧臭氧 (O3) 引起的气道炎症.
- 阐明潜在的机制,包括氧化应激,微生物群变化和代谢变化.
主要方法:
- 小鼠被暴露在过空气,O3,HT或HT+O3中,每天4小时,持续5天.
- 支气管洗液 (BALF) 和肺组织分析了氧化应激,炎症,微生物群组成 (16S rRNA测序) 和代谢概况.
- 对肺组织进行了组织学检查.
主要成果:
- 臭氧暴露诱导了呼吸道氧化应激和炎症,同时暴露于高温会显著恶化.
- 高温暴露放大了O3诱导的有益细菌 (Firmicutes,Allobaculum) 在呼吸道中的减少.
- 同时暴露于高温促进了O3诱导的呼吸道代谢障碍.
结论:
- 高温暴露加剧了O3诱导的气道炎症和氧化应激.
- 恶化可能由HT诱导的气道微生物群和新陈代谢的调节介导.
- 研究结果强调了空气污染物和热量对呼吸系统健康的联合风险.
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