相关实验视频
Updated: Jul 17, 2025

06:09
Quantification of Tumor Cell Adhesion in Lymph Node Cryosections
Published on: February 9, 2020
12.1K
天生的淋巴细胞在癌症转移中的作用
Julia Moreno-Vicente1, Timotheus Yf Halim1
1University of Cambridge, CRUK Cambridge Institute, Cambridge CB2 0RE, UK.
The international journal of biochemistry & cell biology
|September 4, 2023
概括
天生的淋巴细胞 (ILCs) 通过塑造瘤微环境,在癌症转移中发挥着至关重要的作用. 了解ILC功能是开发针对转移性传播的新癌症疗法的关键.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
背景情况:
- 转移是大多数癌症死亡的原因,涉及瘤细胞和宿主微环境之间的复杂相互作用.
- 在二级器官中建立亲瘤原生环境的细胞和分子机制尚未完全理解.
- 天生的淋巴细胞 (ILC) 正在成为癌症免疫反应的关键调节者.
研究的目的:
- 审查有关先天性淋巴细胞 (ILCs) 在癌症转移中的作用的现有证据.
- 讨论ILCs如何影响转移前的利基,并协调免疫细胞的招募.
- 探索不同ILC子集对转移性进展的多样化影响.
主要方法:
- 关于研究癌症转移中的先天性淋巴细胞 (ILCs) 的文献综述.
- 对瘤微环境中ILC与瘤细胞和免疫细胞相互作用的研究分析.
- 综合了有关各种ILC子集类效应的发现.
主要成果:
- 天生的淋巴细胞 (ILC) 在组织中处于战略位置,以响应早期转移的线索.
- ILCs可以协调其他免疫细胞的招募,从而影响转移是否得到支持或抑制.
- 不同的ILC子集在转移级联中表现出各种各样的,有时是对立的角色.
结论:
- 天生的淋巴细胞 (ILCs) 是癌症转移的建立和进展的关键参与者.
- 准ILC及其功能是对抗转移性疾病的潜在治疗策略.
- 需要进一步的研究,以充分阐明不同ILC子集在转移中的复杂作用.
相关概念视频
Metastasis
5.6K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.6K
Cancer Cell Migration through Invadopodia
2.3K
Invadosome is a broad category of cell surface structures with proteolytic activity that degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
2.3K
Functions of the Lymphatic and Immune System
3.7K
The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
3.7K
Introduction to Lymphatic and Immune System
2.8K
Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are...
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are...
2.8K
Lymphoid Cells and Tissues
1.2K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
1.2K
Cells of the Adaptive Immune Response
1.0K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
1.0K

