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Updated: Jul 17, 2025

A Fluorescent Screening Assay for Identifying Modulators of GIRK Channels
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通过liquiritigenin和结构基础抑制AKR1Cs

Huan Liu1, Ziqing Yao1, Mingna Sun1

  • 1Key Laboratory of Molecular Target & Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, China.

Chemico-biological interactions
|September 4, 2023
PubMed
概括

甘中的一种化合物Liquiritigenin (LQ) 抑制了在荷尔蒙依赖癌症中至关重要的AKR1C酶. 了解这种机制有助于开发新的前列腺癌和乳腺癌抗瘤疗法.

关键词:
在 AKR1Cs 中.晶体结构 水晶结构.抑制抑制的抑制作用液态基因因的存在选择性的选择性

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