质敏感性 潜在的耐药性"喉回流"症状和迹象
Bailey Balouch1, Lauren E Melley2, Heather Yeakel3
1Drexel University College of Medicine, Philadelphia, Pennsylvania.
无质饮食显著改善了耐药喉回流 (LPR) 和对质敏感症患者的症状和客观测量. 建议这种饮食改变,特别是当血液测试表明对质敏感时.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 喉回流 (LPR) 是一种常见的耳鼻喉病.
- 质敏感性可以模仿或加重LPR症状,特别是在抗标准治疗的情况下.
- 识别质敏感性可能为耐火性LPR提供另一种治疗途径.
研究的目的:
- 为了研究质敏感性和LPR之间的关系.
- 评估无质饮食在改善耐性LPR和阳性质敏感性标志物患者的反流检测得分 (RFS) 和症状方面的有效性.
- 为了确定对无质饮食的积极反应的预测因素.
主要方法:
- 成年患者患有耐治疗的LPR症状/迹象,接受了对质敏感性的测试.
- 具有阳性质敏感性标记的患者被建议参加无质饮食试验.
- 对照组包括那些没有试用饮食的人或对质敏感性标志物的检测结果为负.
- 回流检测得分 (RFS) 作为主要结果指标.
主要成果:
- 与对照组相比,试用无质饮食的患者的客观RFS改善率 (77.14%) 和主观症状改善率 (55.41%) 显著提高.
- 在无质饮食组中,在多次随访间隔内,RFS从基线显著下降.
- 与对照组相比,无质饮食显示出明显更大的RFS改善,即使在检测阳性但没有试用饮食的患者中也是如此.
结论:
- 质敏感性是一种潜在的促成因素或模仿LPR.
- 无质饮食是耐性LPR患者的可行的治疗选择,特别是那些具有阳性质敏感性血液测试的患者.
- 建议至少进行三个月的无质饮食,以观察客观的RFS改善.
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