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Updated: Jul 17, 2025

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
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Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

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探索瘤微环境中的内皮细胞,免疫细胞和免疫检查点之间的交叉连接:新的见解和治疗影响

Jianwen Fang1, Yue Lu2, Jingyan Zheng3

  • 1Department of Breast Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, 310003, Hangzhou, China.

Cell death & disease
|September 4, 2023
PubMed
概括

了解瘤微环境 (TME) 是癌症免疫治疗的关键. 本研究探讨了TME内的内皮细胞 (ECs),免疫细胞和免疫检查点之间的复杂相互作用,以找到新的治疗点.

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The Tumor Microenvironment02:17

The Tumor Microenvironment

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Regulation of Angiogenesis and Blood Supply

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Metastasis02:30

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
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Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
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