结肠胆与Candida tropicalis相关,促进腹和病原体清除
Xihong Zhou1,2,3, Yiwen He1,4, Jingqing Chen5
1Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, the Chinese Academy of Sciences, Changsha, China.
NPJ biofilms and microbiomes
|September 4, 2023
概括
腹涉及肠道真菌,如热带菌. 减少真菌的存在导致胆的积累,导致腹和病原体清除通过改变肠道平衡.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 腹与肠道微生物群的变化有关,但真菌的作用尚未得到充分研究.
- 众所周知,共生细菌会影响肠道健康,但菌群对腹的影响尚不清楚.
研究的目的:
- 研究真菌,特别是Candida tropicalis在腹病原发生中的作用.
- 探索真菌丰富度,宿主免疫反应和腹期间代谢变化的关系.
主要方法:
- 在腹和健康小猪身上对肠道菌群的比较分析.
- 在结肠组织中评估反应性氧物种 (ROS) 和中性粒细胞外细胞陷 (NETs).
- 使用dectin-1-knockout小鼠研究真菌与宿主相互作用和ROS介导的真菌清除.
主要成果:
- 在腹的小猪身上观察到Candida tropicalis丰度的减少.
- 在腹小猪的结肠中发现了增加的ROS和NET形成,导致C. tropicalis通过dectin-1清除.
- 降低C. tropicalis导致胆消耗减少,导致胆积,随后促进腹和病原体清除.
结论:
- 热带菌 (Candida tropicalis) 通过摄入胆来维持肠道代谢平衡.
- 由降低的C. tropicalis驱动的胆积,有助于腹,有助于清除致病细菌.
- 肠道菌群可能对调节肠道代谢平衡和宿主防御机制至关重要.
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