相关实验视频

Updated: Jul 17, 2025

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Published on: December 18, 2016

血硬质素升高与认知正常的老年人脑中的高粉样β负载有关

Jun Yuan^1,2, Steve Pedrini³, Rohith Thota⁴

¹Perron Institute for Neurological and Translational Science, Nedlands, WA, Australia.

|September 4, 2023

概括

血硬质素 (SOST) 水平在患有粉样β (Aβ) 大脑斑块的个体中较高,这是阿尔茨海默病 (AD) 的标志. 升高的SOST可能有助于检测临床前AD,当与其他血液生物标志物相结合时.

科学领域:

生物化学生物化学
神经学神经学
老年学是一门学科.

背景情况:

骨质疏松症和阿尔茨海默病 (AD) 在老年人中具有共同的流行病学联系,但潜在的联系仍未得到充分研究.
大脑中的β-粉样蛋白 (Aβ) 斑块是AD的关键病理特征.

研究的目的:

为了研究血硬质素 (SOST) 水平和大脑Aβ负载在认知不受损的老年人之间的关联.
评估SOST作为临床前AD检测的潜在生物标志物.

主要方法:

根据Aβ-PET成像,参与者被分为Aβ- (n=65) 和Aβ+ (n=35) 组.
血SOST,APOE基因型和AD血液生物标志物 (Aβ40,Aβ42,NFL,GFAP,tau变体) 被测量和比较.

主要成果:

与Aβ-组相比,Aβ+组的血SOST水平明显高于Aβ-组 (P <0.01).
血SOST度与大脑Aβ负载正相关 (ρ = 0.321,P = 0.001).
将血SOST与Aβ42 / Aβ40比率相结合,改善了检测临床前AD的曲线下面积 (AUC) (0.768对0.669,P = 0.027).

结论:

在具有高AD风险的认知正常个体中,血SOST水平升高.
SOST显示出作为辅助生物标志物的潜力,有助于检测临床前阿尔茨海默病.

更多相关视频

Full- versus Sub-Regional Quantification of Amyloid-Beta Load on Mouse Brain Sections

Full- versus Sub-Regional Quantification of Amyloid-Beta Load on Mouse Brain Sections

Published on: May 19, 2022

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Published on: March 7, 2019

相关概念视频

Alzheimer's Disease: Overview

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...

Amyloid Fibrils

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...