分离传感运动条纹体对自动和视觉引导运动序列的贡献
Kevin G C Mizes1,2, Jack Lindsey3, G Sean Escola3,4
1Program in Biophysics, Harvard University, Cambridge, MA, USA.
Nature neuroscience
|September 4, 2023
概括
基底腺节对于自动运动技能至关重要,就像练习的序列一样,但对于有线索的运动来说不那么重要. 这项研究阐明了它们在运动控制和学习中的独特作用.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 行为神经科学 行为神经科学
背景情况:
- 灵活的运动行为允许适应,但在计算上要求很高.
- 重复的练习可以导致自动,轻松的动力序列执行.
- 在灵活和自动的序列执行中,基底质的作用尚未完全被理解.
研究的目的:
- 为了研究基底质对视觉引导与自动运动序列的差异性贡献.
- 为了确定基底细胞如何支持运动技能的学习和执行.
主要方法:
- 鼠被训练在被指导的运动序列和自我启动的自动序列上.
- 神经记录在传感运动条纹体中进行.
- 损伤研究是为了评估损伤对运动行为的影响而进行的.
主要成果:
- 在传感运动条纹体中发现了一种运动代码,独立于执行模式.
- 在这两种条件下,基底腺瘤的损伤同样影响了速度和动力学.
- 病变显著破坏了自动序列的高层结构,但并没有破坏指令序列.
结论:
- 基底腺节对于执行由连续动力学定义的自动运动技能至关重要.
- 基底腺可能不需要用于由外部感官线索引导的离散运动序列.
- 这凸显了基底在不同类型的运动学习和控制中的不同角色.
相关概念视频
Indirect Motor Pathways
1.6K
The indirect motor or extrapyramidal pathways originate in the brainstem, the lower portion of the brain that connects it to the spinal cord. They consist of several distinct tracts, each with specialized functions. The four main tracts of the indirect motor pathways are the vestibulospinal tract, the reticulospinal tract, the tectospinal tract, and the rubrospinal tract.
The vestibulospinal tract originates in the vestibular nuclei of the brainstem. The vestibular system detects changes in...
The vestibulospinal tract originates in the vestibular nuclei of the brainstem. The vestibular system detects changes in...
1.6K
Hierarchy of Motor Control
2.8K
The hierarchy of motor control refers to the different levels of organization and processing involved in controlling movement in the body. These levels range from higher cortical areas involved in planning and decision-making to lower spinal cord reflexes that respond automatically to external stimuli.
2.8K
Direct Motor Pathways
2.1K
The direct motor pathways, also known as the pyramidal tracts, are a group of neural pathways that originate in the brain and descend through the spinal cord. They control the voluntary movement of the body. There are two major direct motor pathways: the corticospinal and the corticobulbar tracts.
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
2.1K
Motor and Sensory Areas of the Cortex
4.0K
The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
4.0K
Diencephalon: Thalamus and Information Relay
1.7K
The thalamus, often called “the gateway to the cerebral cortex,” is vital in processing and directing sensory and motor signals throughout the brain. Almost all inputs destined for the cerebral cortex, except for olfactory signals, are relayed through the thalamus. The thalamus is a sophisticated relay station, channeling information from various brain regions to the cerebral cortex, as well as a filter, prioritizing certain signals over others based on current physiological...
1.7K
Major Somatic Sensory Pathways
1.0K
Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
1.0K


