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Updated: Jul 17, 2025

Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

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在YAP-TEAD复合物促进衰老细胞的存活,通过降低内分泌网膜应激应激降低衰老细胞的存活

Carlos Anerillas1, Krystyna Mazan-Mamczarz2, Allison B Herman2

  • 1Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA. carlos.anerillasaljama@nih.gov.

Nature aging
|September 4, 2023
PubMed
概括

这项研究表明,脊氨酸 (VPF) 通过抑制YAP-TEAD通路来消除衰老细胞,通过内质网膜应激触发细胞亡. 在老年小鼠中,VPF治疗改善了组织稳态.

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