老年人中SARS-CoV-2疫苗突破性感染:元分析和系统审查
Xiaohui Jing1, Menglin Han2, Xiaoxuan Wang2
1School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, 10 Poyang Lake Road, Tianjin, 301617, P.R. China. m18838738921@163.com.
BMC infectious diseases
|September 4, 2023
概括
这次元分析发现,老年人中COVID-19突破性感染的流行率和发病率较低. 在这个人群中,突破性感染的严重结局也显着较低.
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 疫苗学 疫苗学 疫苗学
背景情况:
- 针对COVID-19 mRNA疫苗的疫苗有效性下降导致突破性感染的增加.
- 老年人是一个脆弱的群体,需要特别注意疫苗的有效性和感染率.
研究的目的:
- 对老年人SARS-CoV-2突破性感染的流行率和发病率进行全球元分析.
- 为此群体提供COVID-19突破性感染率的综合估计.
主要方法:
- 在PubMed,Embase,Cochrane图书馆和Web of Science的系统文献搜索到2022年11月2日.
- 包括30项以英语出版的基于人口的研究.
- 使用逆方差方法进行随机效应模型元分析,并遵循PRISMA指南.
主要成果:
- 在老年人中,COVID-19突破性感染的综合流行率为每1000人7.7.
- COVID-19突破性感染的综合发病率为每1000人年29.1.
- 在突破性感染中,住院率,严重危急疾病和死亡率明显降低.
结论:
- 老年人中SARS-CoV-2突破性感染的流行率和发病率较低.
- 在这个年龄组中,突破性感染的严重后果大大减少.
- 研究估计之间的异质性需要仔细解释结果.
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