增加父亲的皮质类固醇暴露会影响后代的行为和尿激素的表达
Lucas B Hoffmann1,2, Evangeline A McVicar1,3, Rebekah V Harris1,3
1The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia.
BMC biology
|September 4, 2023
概括
在小鼠中,父亲的压力暴露改变了后代的社会行为和吸引力,但在孙子后代中没有看到影响. 这表明,中度的父亲压力可能会影响代际适应性反应.
科学领域:
- 行为表观遗传学 行为表观遗传学
- 进化生物学是进化的生物学.
- 生殖科学 生殖科学
背景情况:
- 怀孕前的父亲压力可以影响后代的先天行为.
- 压力的代际影响具有显著的进化影响.
- 以前的研究表明,父亲的压力增加了男性后代的焦虑.
研究的目的:
- 研究父亲压力对后代社会行为的跨代影响.
- 评估父亲压力对生殖成功的影响.
- 探索这些影响背后的表观遗传机制.
主要方法:
- 在F1和F2世代中评估了社会参数 (奖励,吸引力,主导地位).
- 使用牛津纳米孔测序分析精子DNA甲基化.
- 在F1后代中检查了前额叶皮层转录组.
主要成果:
- 父亲的皮质激素治疗导致男性后代的服从性增加.
- 后代对雌性更有吸引力,尽管费洛蒙 (达尔辛) 水平降低.
- 没有发现Mup基因或转录组变化的表观遗传差异;F2代没有表型差异.
结论:
- 适度的父亲压力可以诱导代际适应性/不适应性反应.
- 这些发现为研究动物,人类和其他物种的适应性提供了信息.
- 外围机制,而不是Mup基因或大脑转录组的直接表观遗传变化,可能会产生影响.
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