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一种新的光学连贯性断层扫描血管造影流量指数在一次性开放角玻璃眼的队列中的有效性

Ahmed Ameen Ismail¹, Sherin Sadek², Mahmoud Kamal²

¹Department of Ophthalmology, Faculty of Medicine, Fayoum University, Al Fayoum, Egypt. am178@fayoum.edu.eg.

BMC ophthalmology

|September 4, 2023

概括

新的数学流量指数 (FIM) 为基于强度的OCTA流量指数 (FIO) 提供可靠的替代方案,用于眼血管评估. 这些新型指数可以克服诸如光连贯断层扫描血管学 (OCTA) 速度计中的信号和等局限性.

科学领域:

眼科医生眼科眼科
生物医学工程生物医学工程
医疗成像医学成像

背景情况:

血管机制在许多眼部疾病中至关重要,需要先进的成像技术.
光学连贯断层扫描血管造影 (OCTA) 提供高分辨率的3D血管成像,但由于信号和而面临量化流量数据的局限性.
现有的OCTA速度测量方法容易出现错误,这凸显了需要更强大的定量测量方法的需要.

研究的目的:

引入和验证新的数学OCTA流量指数 (FIM),旨在克服当前OCTA速度计方法的局限性.
评估这些新的FIM与已建立的基于强度的OCTA流量指数 (FIO) 的可靠性和相关性.
探索FIMs在补偿OCTA信号和方面的潜力,特别是在变化的平均眼 perfusion 压力 (MOPP) 下.

主要方法:

这项研究包括来自23名患有初级开角青光眼 (POAG) 患者的37只眼睛.
进行了斑点和视神经头部 (ONH) 的OCTA成像,以及内血压和全身动脉血压 (SABP) 测量.
基于强度的流量指数 (FIO) 被计算出来,数学流量指数 (FIM) 使用血管密度和MOPP,基于哈根-波塞尔定律.

主要成果:

在基线和随访时,在新型FIM和相应的FIO之间观察到中等到高的正相关性.
类内相关系数 (ICCs) 表示表面血管数学流量指数 (SFIM) 和视神经头血管数学流量指数 (ONHFIM) 的可靠性很好.
虽然深血管数学流量指数 (DFIM) 的可靠性较低,但它仍然超过了相应的基于强度的指数 (DFIO).

结论:

新开发的数学流量指数 (FIM) 作为基于强度的OCTA流量指数 (FIO) 的可靠替代品.
这些FIM显示出缓解OCTA信号和问题的潜力,特别是在一系列的平均眼球 perfusion 压力 (MOPP).
SFIM和ONHFIM具有高可靠性,表明它们的临床实用性,而DFIM,尽管可靠性较低,但与DFIO相比,显示出有前途.

关键词:

流量指数是指流量指数.眼光障碍症眼光障碍症眼光障碍症哈根-波西耶尔定律是什么?数学模型是一个数学模型.光学连贯性断层扫描血管图谱

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