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来自不同植物来源的无刺蜜蜂蜂蜜的抗过敏潜力通过调节巨细胞脱粒的调节

Poi Yi Aw Yong¹, Ashley Jia Wen Yip¹, Fahmida Islam^1,2

¹School of Science, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, Subang Jaya, 47500, Selangor, Malaysia.

BMC complementary medicine and therapies

|September 4, 2023

概括

无刺蜂蜜 (Kelulut蜂蜜) 通过抑制人类巨细胞中的炎症媒介来表现出抗过敏性质. 它的有效性因植物来源而异,竹子和树蜂蜜显示为治疗过敏的最有希望的方法.

科学领域:

免疫学免疫学免疫学
药理学药理学是指药理学的学科.
自然产品化学化学

背景情况:

过敏影响全球20%的人口,引发对自然疗法的兴趣.
无刺蜂蜜 (Kelulut蜂蜜,KH) 是马来西亚传统的治疗呼吸道疾病的药物.
这项研究调查了来自各种植物来源的KH的抗过敏潜力.

研究的目的:

为了评估Kelulut蜂蜜 (KH) 对激活的人类乳腺细胞的抗过敏作用.
为了确定植物起源对KH抗过敏活性的影响.
识别KH中的植物化学物质及其潜在的分子标.

主要方法:

在激活的人类巨细胞 (HMC) 中评估了炎症媒介 (TNF-α,IL-4,IL-6,IL-8,基因组胺,β-hexosaminidase) 的抑制.
量化总含量 (TPC) 和使用LC-MS/MS识别的植物化学物质.
采用计算方法 (分子对接) 来预测分子相互作用.

主要成果:

竹子 (BH) 和树 (RH) 的 KH 显著抑制了炎症媒介的释放.
BH和RH表现出更高的TPC和更丰富的植物化学特征.
计算分析表明,KH可能针对下游的MAPK.

结论:

凯鲁特蜂蜜显示出对激活的人类乳腺细胞的抗过敏潜力.
抗过敏疗效取决于蜂蜜的植物来源.
KH 是一种对过敏性疾病的补充疗法.

关键词:

抗过敏的抗过敏的这是一种抗炎症药物.植物来源植物来源人类巨细胞是人类的巨细胞.在状的中.凯鲁特蜂蜜是什么意思凯鲁特蜂蜜是什么意思这就是PMACI.聚醇是一种多醇.没有刺的蜜蜂蜂蜜.

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