ACE和ACE2基因的基因型变异影响COVID-19患者的严重程度
Ingrid Faustine1,2, Deli Marteka1, Amarila Malik3
1Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, West Java, Indonesia.
BMC research notes
|September 4, 2023
概括
在ACE和ACE2基因的遗传变异,以及高血压,显著影响印尼人的COVID-19严重程度. 与高血压相结合的特定基因型 (ACE rs4331,ACE2 rs2074192) 与中度至重度疾病相关.
科学领域:
- 遗传学 是一个遗传学.
- 心血管医学 心血管医学
- 传染性疾病 传染性疾病
背景情况:
- ангиотензин转化酶 (ACE) 和ACE2基因中的遗传多态性通过Renin-Angiotensin系统 (RAS) 影响血压调节.
- 这些遗传变异可能会使个体易患高血压,并在SARS-CoV-2病变和COVID-19严重性中发挥作用.
- 了解这些关联对于预测和管理严重的COVID-19结果至关重要,特别是在高高血压患病率的人群中.
研究的目的:
- 调查ACE (rs4331) 和ACE2 (rs2074192) 基因的遗传变异与高血压并发症之间的关联.
- 确定这些遗传变异和高血压对印尼人口COVID-19严重程度的影响.
主要方法:
- 一项涉及186名患者的横截面研究,分为COVID-19 (n=95) 和非COVID-19 (n=91) 组.
- 进行了ACE (rs4331) 和ACE2 (rs2074192) 多态的基因定型.
- 使用统计分析来比较基因型频率,并评估与COVID-19严重程度和高血压的相关性.
主要成果:
- 两组之间ACE基因的GG基因型频率没有显著差异 (p=0.163).
- 观察到ACE2基因的CC基因型频率存在显著差异 (0.37与0.01,p=0.000).
- 高血压并发症,特别是在男性中,以及特定的基因型 (ACE:GG,ACE2:TT/CT) 与中度至重度的COVID-19症状有关,男性 (25%) 和女性 (21%) 的比例更高.
结论:
- 高血压是导致COVID-19严重程度的一个重要因素.
- 在ACE (rs4331) 和ACE2 (rs2074192) 基因的遗传变异,与高血压结合,影响COVID-19疾病的严重程度.
- 这些发现突出了遗传倾向,并发症和传染病结果之间的相互作用.
关键词:
这就是ACE基因,ACE基因.这种ACE2基因是ACE2基因.在 COVID-19 疫情中,高血压是一种共生性疾病.印度尼西亚人口 印度尼西亚人口rhAmp SNP 基因型鉴定rs2074192 的使用费用.需要 rs4331 才能使用更多相关视频
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