随着时间的推移,COVID-19对系统性硬化症患者的影响是否会改变?
Elisabeth Deibel1, Patricia E Carreira2, Madelon Vonk3
1University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Arthritis care & research
|September 5, 2023
概括
患有全身性硬化症 (SSc) 和COVID-19的患者的结果在流行病浪潮中显著改善. 较少的SSc患者经历了严重的COVID-19,由于不断变化的因素,在后来的波浪中住院或死亡.
科学领域:
- 类风湿病学 类风湿病学
- 传染性疾病 传染性疾病
- 临床结果 临床结果
背景情况:
- 对于各种患者群体而言,COVID-19的结果在整个大流行期间有所改善.
- 关于COVID-19结果,特别是系统性硬化症 (SSc) 患者的数据仍然有限.
- 了解COVID-19期间SSc患者的结果对于有针对性的管理至关重要.
研究的目的:
- 为了评估被诊断患有系统性硬化症 (SSc) 和COVID-19的患者在不同流行病浪潮中的结果.
- 为了识别随着时间的推移疾病严重程度,住院率和死亡率的变化.
- 探索影响这一脆弱患者群体结果的因素.
主要方法:
- 追溯分析333名SSc患者的COVID-19来自欧洲结核病试验和研究 (EUSTAR) 组 (2020年4月至2021年4月).
- 根据COVID-19诊断日期将患者分为三个波.
- 主要终点包括死亡,ICU入院或机械通风;采用子组分析和后勤回归.
主要成果:
- 与第一波相比,在后一波中,严重的COVID-19结局 (28.2%与9.8-12.7%相比),住院 (46.7%与19.6-25.5%相比) 和死亡率 (15.7%与5.0-7.5%) 显著下降.
- 后一波的患者年轻,男性更频繁,动脉高血压和心脏干扰较少.
- 对SSc治疗中,中高剂量的皮质类固醇的使用减少,在波段上被注意到.
结论:
- 在大流行期间,系统性硬化症患者的COVID-19结果已大大改善.
- 这种改善归因于患者内在因素和外在因素的结合,例如不断变化的医疗管理和治疗策略.
- 持续监测和研究对于在传染病爆发期间进一步优化SSc患者的护理至关重要.
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