延迟食道解剖症并发症和拉穆西鲁马布治疗:一个病例报告
Robert H Roth1, Madison J Malfitano2, Matthew Reilley3
1Department of Anesthesiology, Dartmouth-Hitch Medical Center, Lebanon, New Hampshire, USA.
Thoracic cancer
|September 5, 2023
概括
一个罕见的食道解剖泄漏病例发生在一个患者身上,该患者接受了用于治疗复发性食道胃癌的VEGF抑制剂ramucirumab的治疗. 这突显了VEGF抑制剂在食道切除术后患者的潜在风险.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 手术瘤学手术瘤学
背景情况:
- 建议使用血管内皮生长因子 (VEGF) 抑制剂作为复发性或转移性食道胃癌的二线治疗.
- 维格F抑制剂与胃肠道穿孔和晚期结肠直肠静脉泄漏有关.
研究的目的:
- 在接受ramucirumab的患者中报告晚期食道异位泄漏的病例.
- 提高对VEGF抑制剂在食道切除术后患者的潜在风险的认识.
主要方法:
- 病例报告详细介绍患者的治疗史和结果.
- 对电子医疗记录进行审查,以获取患者信息.
主要成果:
- 一名患有晚期食管胃腺癌的患者在开始服用帕克利塔克塞尔和拉穆西鲁马布16周后出现了食管肺.
- 这种并发症发生在解肠裂的区域,食管切除术后16个月.
- 患者死于渐进的肺炎,活检结果呈异位瘤复发阴性.
结论:
- 这是第一次报告与拉穆西鲁马布相关的延迟食道解并发症的病例.
- 这些发现表明,在经食道切除术后复发的患者中使用VEGF抑制剂时需要谨慎,因为可能出现罕见但致命的静脉关节并发症.
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